Get Beginnings of Cellular Life: Metabolism Recapitulates PDF

By Professor Harold J. Morowitz

ISBN-10: 0300054831

ISBN-13: 9780300054835

During this ebook, Harold Morowitz offers a brand new thought at the beginning of existence in the world 4 billion years in the past. Morowitz postulates that step one towards the beginning of lifestyles was once the spontaneous condensation of amphiphilic molecules to shape vesicles or protocells. This speculation presents a framework for reexamining the emergence of cellularity. Morowitz extra proposes that center metabolic techniques haven't replaced for a few 3.8 billion years, so that you can use a examine of recent biochemistry to improve our wisdom in regards to the chemical tactics of the earliest protocells. Morowitz perspectives foundation of existence concerns from the persepective of definite constructs within the philosophy of technology that supply guideposts to formulating and assessing hypotheses

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Additional resources for Beginnings of Cellular Life: Metabolism Recapitulates Biogenesis

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Cellular particulate glycogen is abundant. Most of the cells have clearly spherical mitochondria with cristae of the tubular type. Some cells have vesicular mitochondria as in the zona fasciculata (see Rohr et ai, 1976). Some mitochondria show strange configurations. The tubules, parallel to each other, follow a curvilinear course, concentric with the mitochondrial envelope, thus giving a mitochondrion a pseudolamellar internal structure in some sections, in others a honeycomb appearance. Other mitochondria appear flattened or cup-shaped, often including a portion of the cytoplasm or even a liposome (Idelman, 1964a).

It is found in many mammals but with a sporadic distribution (Gospodinov and Davidoff, 1971). Paradoxically, hypophysectomy results in an increase of the activity of this enzyme throughout the whole cortex. Perhaps this is a result of the compensatory supply THE STRUCTURE OF THE MAMMALIAN ADRENAL CORTEX 35 of steroids from the conjugated molecules from the liver to replace the decreased biosynthesis after operation. (iv) Lipase {esterase) activity, Lipid metabolism is high in the adrenal cortex and a-naphthol acetate (acetylnaphtholesterase) is a good marker.

1969), some hibernators (Deane and Lyman, 1954) or some ruminants (Nicander, 1952). , 1948; see Section 9). The lipid itself is made up of a mixture of cholesterol and its esters (among which the sulphates represent an important pathway of biosynthesis, Baulieu, 1962), palmitic, stearic and oleic esters of glycerol, the steroid hormones themselves and precursors (Pearse, 1972). , 1972). The comparative TABLE III Volumes occupied by liposomes in the adrenocortical zones of three species. 3 Reticularis 28 S.

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Beginnings of Cellular Life: Metabolism Recapitulates Biogenesis by Professor Harold J. Morowitz

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