Autoimmune Diseases in Endocrinology - download pdf or read online

By Sonia Quaratino MD,PhD (auth.), Anthony P. Weetman MD,DSc (eds.)

ISBN-10: 1588297330

ISBN-13: 9781588297334

ISBN-10: 1597455172

ISBN-13: 9781597455176

Autoimmune ailments in Endocrinology is a complete and novel textual content that examines key gains that predispose members to autoimmune ailments. The textual content starts with 3 introductory chapters which supply enough info in order that somebody, together with these and not using a historical past in fresh immunology, can be in a position to comprehend the advancements within the box. the following and biggest component to the publication matters autoimmune thyroid affliction, and authors of those chapters take the reader during the simple epidemiology, genetic and environmental hazard components, immunopathogenesis, and the diagnostic and administration point of the illness. the subsequent part discusses kind 1 diabetes mellitus. within the ultimate part, authors clarify different autoimmune endocrinopathies, together with Addison’s sickness, untimely ovarian failure, autoimmune hypophysitis, and autoimmune polyglandular syndrome forms 1 and a pair of. finished and well timed, Autoimmune illnesses in Endocrinology becomes a necessary reference for all endocrinologists and inner medication practitioners operating during this field.

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HL-A antigens and diabetes mellitus. Lancet 1974;2(7885):864–6. 55. Giordano M, D’Alfonso S, Momigliano-Richiardi P. Genetics of multiple sclerosis: linkage and association studies. Am J Pharmacogenomics 2002;2(1):37–58. 56. Newton JL, Harney SM, Wordsworth BP, Brown MA. A review of the MHC genetics of rheumatoid arthritis. Genes Immun 2004;5(3):151–7. 57. Heward JM, Allahabadia A, Daykin J, et al. Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves’ disease: replication using a population case control and family-based study.

In addition, although the incidence of T1DM increased in Finland, it remained stable in the genetically similar populations of Estonia and Russian Karelia. Many studies show only presence of autoantibodies following the onset of an infectious disease, which is far from indicating causality. Only longitudinal, HLAmatched studies can answer the question whether a single virus infection can increase the incidence of an autoimmune disease. If a viral infection acts as an adjuvant in autoimmune disease development, as we have shown in mice, the same autoimmune disease in humans might be triggered by many different viruses.

Virus-induced diabetes mellitus: mengovirus infects pancreatic beta cells in strains of mice resistant to the diabetogenic effect of encephalomyocarditis virus. J Virol 1984;50(3):684–90. 40. Fourneau JM, Bach JM, van Endert PM, Bach JF. The elusive case for a role of mimicry in autoimmune diseases. Mol Immunol 2004;40(14–15):1095–102. 41. Lanzavecchia A. How can cryptic epitopes trigger autoimmunity? J Exp Med 1995;181(6): 1945–8. 42. Salemi S, Caporossi AP, Boffa L, Longobardi MG, Barnaba V. HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing.

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Autoimmune Diseases in Endocrinology by Sonia Quaratino MD,PhD (auth.), Anthony P. Weetman MD,DSc (eds.)

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