Autoantibodies in Neurological Diseases by G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito PDF

By G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito Martino (eds.)

ISBN-10: 8847020972

ISBN-13: 9788847020979

ISBN-10: 8847021634

ISBN-13: 9788847021631

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Patients with VGCC antibodies and cerebellar symptoms often have detectable VGCC antibodies in their cerebrospinal fluid, although the amounts present are compatible with simple diffusion from the serum rather than evidence of intrathecal synthesis (F. Graus, B. Lang and A. Vincent, in preparation). Further studies are required to try to understand why some patients' VGCC antibodies cause CNS involvement and whether effective immunotherapies might be able to improve the ataxia, or at least halt its progress.

Fraser FC, Sajoo A (1995) Teratogenic potential of corticosteroids in humans. Teratology 51:45-46 49. Gaudier FL, Santiago-Delin E, Rivera J , Gonzales Z (1988) Pregnancy after renal transplantation. Surg Gynecol Obstet 167:533-543 50. Schmidt PL, Sims ME, Strassner HT et al (1984) Effect of antepartum glucocorticoid administration upon neonatal respiratory distress syndrome and perinatal infection. Am J Obstet GynecoI178:178-186 51. Tuchmann-Duplessis H, Mercier-Parot L (1996) Production in rabbits of malformations of the limbs by azathioprine and 6-mercaptopurine.

Vincent, 1. Matthews, N. Willcox, in preparation). 2 .! ~20 .... e c •• 10 • • • ..... ••• .. ",,,,,. O~--------------~------------------------ AMC Parous Non-Parous Controls Fig. 1. Antibodies inhibiting the function of fetal acetylcholine receptors in different groups of myasthenia gravis patients and mothers of arthrogryposis babies (AMC). Antibodies that can inhibit the ion channel function of the receptor are more common in women who develop MG during or after pregnancy (Parous) than in those who develop it before pregnancy (Non-Parous) 20 A.

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Autoantibodies in Neurological Diseases by G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito Martino (eds.)


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