Autoantibodies in Neurological Diseases by G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito PDF
By G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito Martino (eds.)
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Patients with VGCC antibodies and cerebellar symptoms often have detectable VGCC antibodies in their cerebrospinal fluid, although the amounts present are compatible with simple diffusion from the serum rather than evidence of intrathecal synthesis (F. Graus, B. Lang and A. Vincent, in preparation). Further studies are required to try to understand why some patients' VGCC antibodies cause CNS involvement and whether effective immunotherapies might be able to improve the ataxia, or at least halt its progress.
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Vincent, 1. Matthews, N. Willcox, in preparation). 2 .! ~20 .... e c •• 10 • • • ..... ••• .. ",,,,,. O~--------------~------------------------ AMC Parous Non-Parous Controls Fig. 1. Antibodies inhibiting the function of fetal acetylcholine receptors in different groups of myasthenia gravis patients and mothers of arthrogryposis babies (AMC). Antibodies that can inhibit the ion channel function of the receptor are more common in women who develop MG during or after pregnancy (Parous) than in those who develop it before pregnancy (Non-Parous) 20 A.
Autoantibodies in Neurological Diseases by G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito Martino (eds.)