Read e-book online Aging is a group-selected adaptation: theory, evidence, and PDF

By Joshua Mitteldorf

ISBN-10: 1315354039

ISBN-13: 9781315354033

ISBN-10: 1498715281

ISBN-13: 9781498715287

ISBN-10: 1498715303

ISBN-13: 9781498715300

Because the Nineteen Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary thought, specifically within the zone of genetics. at the same time, a technology of multilevel choice has came across its position within the evolutionary literature. the writer means that proof warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic thought of senescence, wherein getting older has Read more...

summary: because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary idea, specially within the sector of genetics. at the same time, a technological know-how of multilevel choice has came across its position within the evolutionary literature. the writer means that facts warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic concept of senescence, wherein getting older has been affirmatively chosen since it degrees the dying cost over the years, aiding to stabilize inhabitants dynamics and forestall extinctions

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Extra info for Aging is a group-selected adaptation: theory, evidence, and medical implications

Example text

Exercise hormesis, like the CR effect, is impossible to reconcile with any of the non-programmed theories of aging. But it poses particular difficulty for theories of aging from oxidative damage, since exercise increases oxidative stress and increases lifespan. Exercise is most demanding on mitochondria. It induces mitochondrial oxidative damage and promotes mitochondrial autophagy. According 16 Aging is a Group-Selected Adaptation to the popular mitochondrial free radical theory [75], exercise ought to accelerate aging and antioxidants should offer some mitigation, but the truth is the opposite.

1-31. 92. Jolly, D. and J. Meyer, A brief review of radiation hormesis. Australas. Phys. Eng. Sci. , 2009. 32(4): p. 180-187. 93. , Toxicological awakenings: the rebirth of hormesis as a central pillar of toxicology. Toxicol. Appl. , 2005. 204(1): p. 1-8. 2 Chapter The Diverse Demography of Aging Synopsis This chapter is just for fun and is not logically necessary for the theme of the book. In another sense, this chapter is the core of the book, a broad survey of what theorists have before them to explain.

In the first [56], the timing of daf-2 signals was manipulated via RNA interference to separate effects on lifespan from effects on fertility. Animals in which daf-2 expression was curtailed only after maturation experienced full lifespan extension without incurring the fertility cost. In the second experiment, destruction of the germ line (via laser ablation) was found to lengthen lifespan [57]. If the surrounding gonads were removed with the worm’s germ cells, the effect was negated and no life extension was observed.

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Aging is a group-selected adaptation: theory, evidence, and medical implications by Joshua Mitteldorf


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