Download e-book for iPad: Aging and Cancer by Frederick F. Holmes M.D. (auth.)

By Frederick F. Holmes M.D. (auth.)

ISBN-10: 3642821014

ISBN-13: 9783642821011

ISBN-10: 3642821030

ISBN-13: 9783642821035

The lifetime of a man or woman is finite, and all people age (see Fries 1980). it really is tricky to split the results of ailment on organs and tissues from these anticipated of getting older. this is often really precise for vascular and degenerative procedures, for which there aren't any transparent obstacles among getting older and affliction. Morbidity and mortality from middle disorder and stroke are most likely due either to illness and to adjustments of getting older. For melanoma, the second one top reason behind dying in the United States, the placement is kind of diverse; melanoma is obviously a affliction and isn't a metamorphosis anticipated with getting older. melanoma prevalence raises virtually logarithmically after age forty. within the usa approximately one-half of all situations of melanoma are clinically determined after age sixty five, even supposing these over sixty five include under one-eighth of the inhabitants. therefore, melanoma is especially a lot a sickness of the aged. There are no less than purposes for this: first, the lengthy publicity to cancer-inducing brokers, and moment, the waning strength of immune defenses opposed to cancer.

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3 shows a considerable increase in survival between the two time periods, which is apparent but not significant with the data available, probably because of the relatively small number of cases. J '> a: 50 (/) 40 ::J 30 20 Fig. 2. Years survival by age and time groups for locally confined kidney cancer 10 0 3 65-74 3 75-84 3 85-94 5 Kidney 3 8S-114 Fig. 3. Years survival by age and time groups for regionally spread kidney cancer Fig. 4. Years survival by age and time groups for distantly spread kidney cancer 3 85-94 absolute cure rate at this stage is at least 35%.

The kidney is the Achilles heel of the myeloma patient, and avoidance of dehydration and sludging of protein in renal tubules is of great importance in management. References Brook J, Bateman JR, Gocka EF, Nakamura E, Steinfeld JL (1973) Longterm low dose melphalan treatment of multiple myeloma. Arch Intern Med 131: 545-548 Conklin R, Alexanian R (1975) Clinical classification of plasma cell myeloma. Arch Intern Med 135: 139-143 Hoogstraten B (1981) Mollites et fragilitas ossium. J Kans Med Soc 82: 463-465 Isobe T, Osserman EF (1971) Pathologic conditions associated with plasma cell dyscrasias, a study of 806 cases.

3. There are even some deaths from the cancer after 5 years. Unfortunately there are not enough cases to allow comparison between the two time periods or to plot a survival curve at all for the oldest group. This stage accounts for about 25%-30% of all ovarian cancers, and most women die with or of this cancer in this stage. Some women are cured at this stage, but not many. There are two clear challenges for this stage. The true cure rate, which is probably about 15% overall, might be improved by chemotherapy and/or radiotherapy adjuvant to potentially curative surgery, similar in concept to current management of regionally spread breast cancer.

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Aging and Cancer by Frederick F. Holmes M.D. (auth.)


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