Advances in Alzheimer's and Parkinson's Disease: Insights, - download pdf or read online
By Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel Hanin
Proceedings of the seventh overseas convention on Alzheimer’s disorder and Parkinson’s sickness (ADPD), held March 9-13, 2005 in Sorrento, Italy.
The subject material of the ADPD meetings is exclusive in that it offers not just with matters similar separately to Alzheimer’s affliction and Parkinson’s disorder, but in addition with the mixing of those and different similar illnesses. the main updated recommendations and examine findings are illustrated during this quantity, protecting subject matters equivalent to immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the historical past, epidemiology, medical phenomenology, prognosis, imaging, therapy ,and destiny views of Alzheimer’s and Parkinson’s Diseases.
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Additional resources for Advances in Alzheimer's and Parkinson's Disease: Insights, Progress, and Perspectives (Advances in Behavioral Biology)
Visuospatial abstraction and reasoning were found to be more impaired in patients with PDD than in those with AD, whereas visuospatial memory tasks were worse in patients with AD. Impairment becomes especially evident with more complex tasks that require planning and sequencing, so deficits in visuomotor tasks may be partly due to deficits in executive functions . In contrast to prominent visuospatial deficits, another lateralized function, language, seems to be largely preserved. Core language functions are usually normal in PDD; the language deficits consist of mild anomia, rather than the prominent aphasia that develops early in patients with AD.
Oxidative damage is an important mechanism for nigral neuronal death in sporadic PD as well. Clinical features of PARK2 include early-onset (usually at less than 50 years of age) L-dopa-responsive parkinsonism with early development of motor fluctuations (wearing off and dyskinesia) once L-dopa is given. Since gene analysis became possible, however, an age of onset as late as 72 years has been reported . Also, some atypical features such as dementia , psychosis and behavioral problems , cerebellar ataxia , peripheral neuropathy [33,35,36], hyperhydrosis , orthostatic hypotension , urinary urgency and impotence , and hemiparkinsonism-hemiatrophy  have been reported.
These mechanisms involve several DNA surveillance and repair proteins, such as the DNA mismatch repair system (MMR), nucleotide excision repair (NER), and base excision repair (BER) . DNA damage may arise in cells as the result of endogenous and exogenous sources, such as free radical production during cellular metabolism, replication errors, ultraviolet ionizing radiation, and/or mutagenic agents. MMR has been widely investigated because mutations in MMR genes in humans are associated with hereditary nonpolyposis colorectal cancer (HNPCC) and a wide variety of sporadic tumors [2,3].
Advances in Alzheimer's and Parkinson's Disease: Insights, Progress, and Perspectives (Advances in Behavioral Biology) by Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel Hanin