Cheryl L. Scudamore's A Practical Guide to the Histology of the Mouse PDF

By Cheryl L. Scudamore

ISBN-10: 1119941202

ISBN-13: 9781119941200

A sensible advisor to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse types of affliction are used largely in biomedical learn with many thousands of latest versions being generated every year. entire phenotypic research of all of those types can take advantage of histologic assessment of the tissues.

This e-book is aimed toward veterinary and scientific pathologists who're strange with mouse tissues and scientists who desire to review their very own mouse versions. It offers useful advice at the assortment, sampling and research of mouse tissue samples with a view to maximize the data that may be received from those tissues. in addition to illustrating the conventional microscopic anatomy of the mouse, the booklet additionally describes and explains the typical anatomic adaptations, artefacts linked to tissue assortment and historical past lesions to assist the scientist to differentiate those adjustments from experimentally- caused lesions.

This might be an important bench-side better half for researchers and practitioners trying to find an obtainable and well-illustrated consultant to mouse pathology.

  • Written by way of skilled pathologists and in particular adapted to the wishes of scientists and histologists
  • Full color throughout
  • Provides recommendation on sampling tissues, necropsy and recording data
  • Includes universal anatomic diversifications, historical past lesions and artefacts in an effort to aid non-experts comprehend even if histologic adaptations obvious are a part of the conventional heritage or with regards to their experimental manipulation

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Extra info for A Practical Guide to the Histology of the Mouse

Example text

The pericardium should be examined for purulent exudate and fluid and the heart should be examined while attached to the blood vessels and lungs to look for congenital defects. Tumours are occasionally observed in the myocardium. Enlargement of the heart may be observed in cardiomyopathy, which is common in older mice. Cardiomyopathy is a diagnostic term used to describe a spectrum of spontaneous, age-related, degenerative changes, including degeneration, necrosis and increased interstitial fibrous tissue.

45–53. H. P. (1994) Microphthalmia and associated abnormalities in inbred black mice. Laboratory Animal Science 44, 551–560. C. (2003) Factors contributory to early death of young CD-1 mice in carcinogenicity studies. Toxicology Letters 145, 88–98. , Bedigian, H. H. (1994) Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 107, 1726–1735. , King, L. (1996) Cutaneous changes in commonly used inbred mouse strains and mutant stocks, in Pathobiology of the Aging Mouse (eds U.

Unless there is a justifiable reason, a blind review should not normally be recommended as it is unlikely to provide the best possible result. In effect a blind review may be biased if changes are obvious and if the tissues are being evaluated by an experienced pathologist the best use will not be made of their knowledge and interpretive skills. 4 Common spontaneous findings in organs examined from young C57Bl/6 mice in primary phenotyping screens – comparison with CD1 Swiss mice. 5 NA Salivary gland Inflammatory cell foci 13 4 24 39 Stomach Junctional intestinal metaplasia Inflammatory cell infiltrate, submucosa 0 4 1 1 0 8 3 1 Brain Mineralization, thalamus 7 0 0 0 Harderian Gland Inflammation NE NE 40 36 Urinary bladder Inflammatory cell foci 0 0 10 22 Notes: Scudamore unpublished data from C57Bl/6N or C57Bl/6J wild type mice less than 3 months of age from two phenotyping programmes.

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A Practical Guide to the Histology of the Mouse by Cheryl L. Scudamore

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