Download e-book for kindle: A Multidisciplinary Approach to Myelin Diseases II by K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)
By K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)
The illnesses that fall less than the generalized workforce of demyelinating illnesses -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the focal point of globally problem. This quantity comprises papers offered via prime scientists who attended the NATO complex examine Workshop held on the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This ebook is an replace of the former one released in 1987 of the study mentioned at the same assembly held in 1986. It used to be determined to carry this 2d assembly for the reason that there was nice development within the advances in knowing the myelinogenesis procedure within the final 5 years. The workshop collected jointly scientists from many fields similar to mobile and molecular biology, immunology, pathology, virology and naturally medical neurology. Stimulating principles have been exchanged within the desire that extra wisdom of demyelinating illnesses may end up in new theraupetic methods. even though the workshop was once commonly just like the former one, this time there has been extra emphasis on experimental versions and scientific points. within the former using animal and mobile versions as instruments for knowing the pathological mechanisms associated with human affliction have been mentioned; within the latter the clinicians defined the filtering down of uncomplicated learn to medical therapy The book of this interdisciplinary trade is to make recognized the result of the latest learn one of the investigators from allover the area excited about those studies.
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Extra resources for A Multidisciplinary Approach to Myelin Diseases II
Res. 20:545-550 (1992). 11. , Okano, H. Tissue-specific in vitro transcription from the mouse myelin basic protein promoter. Mol. Cell. BioI. 9:3122-3126 (1989). 12. , and Mikoshiba, K. Detection of brain-specific gene expression in brain cells in primary culture: a novel promoter assay based on the use of a retrovirus vector. The New BioI. 4: 53-60 (1991). 13. , Ch. Babinet, M. Monge, S. Timsit, F. Cabon, A. Gansmiiller, M. Miura, S. Sanchez, S. Pournin, K. Mikoshiba, and B. Zalc. The Proximal Region of the MBP Gene Promoter Is Sufficient to Induce Oligodendroglial Specific Expression in Transgenic Mice.
Active zones. , 1992). How proteins are sorted, transported, integrated, and stabilized is just beginning to be A Multidisciplinary Approach To Myelin Diseases II Edited by S. Salvati, Plenum Press, New York, 1994 37 understood. Much of what is known has been obtained from in vitro experiments using simple polarized epithelial cells. As studies explore how surface membranes of more complex cells achieve polarization, additional mechanisms will be identified. The purpose of this review is to summarize current knowledge about protein sorting and targeting in myelinating Schwann cells and to highlight some of the advantages that myelin-forming cells offer for investigating mechanisms of protein targeting.
1991). It turned out that PMP22 expression is axonally regulated like the major myelin genes. , 1993). The open reading frame of the PMP22 cDNA encodes for a 17kDa core protein. The deduced primary structure together with in vitro translation experiments and more recent antibody surveys indicate that PMP22 is a glycosylated integral membrane protein with a molecular weight of 22kDa that is located within the compact myelin of the PNS (Snipes et A MUltidisciplinary Approach To Myelin Diseases II Edited by S.
A Multidisciplinary Approach to Myelin Diseases II by K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)